Course: Three Lessons on Ozone and The Role of Ozone in an Integrative Approach to Treating Cancer
The morning section of this course will be lead by Dr. Silvia Menéndez, PhD. Dr. Menéndez will discuss the following three studies
1.- Ozone Therapy. General protocols based on evidences. Dr. Silvia Menendez, PhD
Ozone has been used as a therapeutical agent for the treatment of different diseases and beneficial effects have been observed. However, ozone biological effects remain controversial due to the scarce knowledge of its biochemical and pharmacodynamic mechanisms. The most remarkable experiences, in preclinical and clinical studies, during the last 30 years, in order to prove unequivocally ozone therapy validity, are presented in this lecture. On the basis of the oxidant properties of ozone, we postulate that controlled ozone administration (named as ozone oxidative pre-/postconditioning mechanism) is able to promote a slight and transient oxidative stress which in turn re-establishes the signalling pathways which have been lost in pathological conditions, preserving the cellular redox balance (increasing antioxidant endogenous system), mitochondrial function as well as the regulation of transcription factors and the modulation of the immunological system. It is evident that membrane-associated ozone peroxides, 4-hydroxialkenals, superoxide anion, nitric oxide, among others, are going to play an important role in cellular signals as well as in the pathology of different diseases. Regulation of these biomolecules by ozone preconditioning has been demonstrated in several preclinical and clinical studies. Nitric oxide modulation, as well as the increase in A1 adenosine receptors achieved with this therapy has an important role in brain blood flux, in the formation of memory, in the release of neurotransmitters and in the inflammatory processes. Ozone therapy seems to induce a simultaneous resuscitation of functions that had gone wrong, reactivating and re-equilibrating physiological activities. This lecture contributes to clarify the ozone mechanism of action and its different pharmacology effects. It is concluded that ozone therapy can be useful in the treatment of several diseases (as neuroinfectious diabetic foot, leg ulcers due to chronic venous and arterial insufficiency, burnt patients, knee osteoarthritis, sudden deafness), either as adjuvant of ortodox medicine or taking part positively in those where conventional therapy has had no success, all this with a common purpose: to favour the patients and contribute to a better quality of life.
2. . Teratogenic Study of Ozone Therapy and its Possible Indications in Obstetrics and Gynecology. Dr. Silvia Menéndez, PhD
Ozone is a powerful oxidant, surpassed, in this regard, only by fluorine. Its doubtless strong reactivity has contributed to establish the dogma that ozone is always toxic and its medical application must be proscribed. However, ozone therapy has been used for therapeutic purposes since the beginning of the last century and its use is increasingly demanded nowadays. For proper enlightenment and guidance of the person interested in the use of ozone for medical purposes, scientific documentation on the safety/toxicity profile of this acclaimed procedure becomes necessary. Taking into account that the National Health Regulatory Agencies require of documentation with scientific trials for sanitary registration of drugs and therapy procedures, different toxicological tests were performed using experimental animals, following the guidelines from the Cuban Regulatory Agency, Food Drug Administration, International Standards Organization and the Health World Organization aimed at proving the safety of ozone therapy administration. In this lecture, the teratogenic study of ozone by rectal insufflation (RI), during 10 sessions, is presented. The number of corpus luteum, implantations, alive and dead fetuses, reabsorptions, as well as the weight and the length cranium-caudal of each fetus were registered. No toxic effect was observed in the pregnant rats subjected to the ozone treatment by RI. It is concluded that no teratogenic nor embriotoxic effects were found after the ozone application by rectal insufflation at the doses studied. With respect to the application of ozone therapy in Obstetrics, an update of the papers published about this topic was presented. They referred the use of ozone therapy in: pregnant womens with hypertension, genital or no genital infections during pregnancy, threatened abortion, intrauterine fetal hypoxia, among others. In Gynecology, an interesting paper was reviewed about distal fallopian tube recanalization using ozone treatment. For inflammatory diseases in female genital organs, intravaginal ozone has been used. Ozone restores the body’s own defense abilities by the normalization of vaginal mucosa local immunity, prevents the generalization of inflammatory processes, facilitates uterus healing, reduces the treatment time with no complications or side effects. The use of ozonated sunflower oil in the treatment of vulvovaginitis, human papillomavirus, acuminate condyloma, genitalis herpes virus with very good results is also presented In summary, we can state that preclinical and clinical studies presented here about the application of ozone therapy in Obstetrics and Gynecology, in the different ways of ozone applications, do not demonstrate any adverse effect or complication. However, more controlled clinical trials are necessary to perform in order to prove the inocuity of ozone therapy, mainly in Obstetrics, where there are still questions to be clarified.
3. Ozone Therapy. Preclinical and Clinical Evidences in the Treatment of Cancer. Dr. Silvia Menéndez, PhD.
In this century, cancer is projected to be the leading cause of death. A report by the WHO foresees that worldwide cancer rates may double by 2020, unless we take stringent measures for promoting a healthy diet, smoking cessation and improved access to viral immunization. The development of an effective cancer therapy is a major focus of biomedical research . There is a total consensus that, whenever possible, the primary tumor must be surgically removed (or irradiated) because large tumor load or extensive metastases induce cachexia and an anergic state. However, a complete ablation and cure is rare because haematogenous dissemination of tumor cells in the bone marrow can occur at an early stage of the malignancy. For that reason, it is not surprising that desperate patients are always looking for other possibilities, particularly in the vast field of complementary medical practices, such as diet, nutrition and lifestyle changes, among others. Neoplasia is a multifactorial process that can be broadly categorized into five etiologies: genetic, viral, chemical, physical and inflammatory. Chemical, physical and inflammatory etiologies are closely linked to reactive oxygen species (ROS), which can readily induce genomic damage. Therefore, the balance between ROS generation and elimination is important for maintaining proper cellular redox states. In this paper we reviewed the state of the art of the different ozone biological effects that were demonstrated, in different animal models, in relation with the possibility to use medical ozone as a therapeutic strategy for cancer treatment. Also, preclinical and clinical studies were performed, in order to demonstrate the effects of ozone. therapy in the treatment of cancer.
The afternoon session of this course will be taught by Dr. Frank Shallenberger, MD.
An Integrative Approach to Cancer Therapy. Dr. Frank Shallenberger, MD
In his Master Class, Dr. Shallenberger, MD, will cover the following topics.
- Prevention – What causes cells to turn cancerous? Clue – it’s got nothing to with carcinogens.The ideal diet for most cancers.
- High Dose IV Vitamin C (HDIVC) protocol
- Natural Adjuvants for various cancer cell types.
- Comprehensive detoxification for cancer therapy
- Hormone therapies for cancer
- Ozone pre-conditioning
- Bergson lipoic acid protocol
- Insulin potentiated chemotherapy
- Radiation protection protocols
- Specific protocols for: colon polyps, bladder cancer, prostate cancer, ER+ PR+ Breast Cancer, melanoma, basal cell cancer, and tumor injection therapy.